一种带有大鼠VL30包装ψ序列的源自鼠白血病病毒的逆转录病毒载体。
A murine leukemia virus derived retroviral vector with a rat VL30 packaging psi sequence.
作者信息
Torrent C, Wang P, Darlix J L
机构信息
LaboRetro INSERM, Ecole Normale Supérieure de Lyon, France.
出版信息
Bone Marrow Transplant. 1992;9 Suppl 1:143-7.
A rat VL30 packaging Psi sequence of 168 nucleotides has been characterized. It bears little or no homology to the Murine Leukemia Virus (MLV) Psi sequence, is much smaller in size and at least as efficient for packaging. The use of this small VL30 Psi sequence in MLV derived retroviral vectors should render even more unlikely recombinations possibly generating replication competent MLV viruses. Thus, utilization of the rat VL30 Psi sequence should improve the biological safety of MLV derived vectors for human gene transfer.
一个168个核苷酸的大鼠VL30包装Psi序列已得到鉴定。它与鼠白血病病毒（MLV）的Psi序列几乎没有同源性，大小要小得多，且包装效率至少相同。在源自MLV的逆转录病毒载体中使用这种小的VL30 Psi序列应会使产生具有复制能力的MLV病毒的重组可能性更小。因此，利用大鼠VL30 Psi序列应可提高源自MLV的载体用于人类基因转移的生物安全性。
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