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Remission rates and significance of prognostic factors in gestational trophoblastic tumors.

作者信息

Ayhan A, Yapar E G, Deren O, Kişnişçi H

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

出版信息

J Reprod Med. 1992 May;37(5):461-5.

PMID:1324312
Abstract

The clinical courses of 82 women with gestational trophoblastic tumors were evaluated in accordance with International Federation of Gynecologists and Obstetricians staging, traditional criteria and the modified World Health Organization prognostic scoring system. The overall remission rate was 79.3% (65/82), and the mortality rate was 20.7% (17/82). All the patients with nonmetastatic stage I disease and all with prognostic scores less than or equal to 4 attained remission, whereas patients at high risk and with stage IV disease had the lowest remission and survival rates. The results support the validity of each system. However, the World Health Organization scoring system, a combination of traditional criteria and International Federation of Gynecologists and Obstetricians staging seemed to be the most reliable for predicting treatment failures.

摘要

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引用本文的文献

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Br J Cancer. 2003 Dec 15;89(12):2197-201. doi: 10.1038/sj.bjc.6601422.
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Persistent gestational trophoblastic disease: results of MEA (methotrexate, etoposide and dactinomycin) as first-line chemotherapy in high risk disease and EA (etoposide and dactinomycin) as second-line therapy for low risk disease.持续性妊娠滋养细胞疾病:甲氨蝶呤、依托泊苷和放线菌素D(MEA)作为高危疾病一线化疗方案以及依托泊苷和放线菌素D(EA)作为低危疾病二线治疗方案的疗效
Br J Cancer. 2000 May;82(9):1547-52. doi: 10.1054/bjoc.2000.1176.