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[速激肽及其与受体相互作用的构象方面]

[Tachykinins and conformational aspects of their interactions with receptors].

作者信息

Avanov A Ia

出版信息

Mol Biol (Mosk). 1992 Jan-Feb;26(1):5-24.

PMID:1324401
Abstract

Several peptides of the tachykinin family are reviewed. Special attention is spared to mammalian tachykinins as peptide neurotransmitters. Conformational possibilities of the tachykinins are considered in connection with their ability to interact with specific receptors. The results of theoretical and experimental studies suggest a significant identity of spatial structures of the tachykinins and explain the absence of the strict specificity in tachykinin-receptor interactions.

摘要

本文综述了速激肽家族的几种肽。特别关注作为肽类神经递质的哺乳动物速激肽。结合速激肽与特定受体相互作用的能力,探讨了其构象可能性。理论和实验研究结果表明,速激肽的空间结构具有显著的一致性,并解释了速激肽 - 受体相互作用中缺乏严格特异性的原因。

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