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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kusama T, Murakoshi Y, Murakami H

Department of Physiology and Anatomy, Nihon University College of Pharmacy, Chiba, Japan.

Gen Pharmacol. 1992 May;23(3):391-6. doi: 10.1016/0306-3623(92)90100-x.

The repetitive application of morphine gradually induced a contracture in the isolated guinea pig ileum. 2. The optimum conditions for induction of the contracture were as follows: the concentration, incubation time and washout time of morphine were 1 or 10 microM, 2 and 3 min, respectively. 3. Preincubation with naloxone or TTX blocked this morphine-induced contracture. 4. Among twitch-inhibiting drugs, only clonidine induced a contracture similar to that induced by morphine, while tetrodotoxin (TTX) and adenosine did not. 5. The contracture was also observed in the longitudinal muscle-myenteric plexus preparations. 6. These findings indicate that morphine has a dual inhibitory and excitatory action on the guinea pig ileum and that its repetitive application preferentially diminish the inhibitory one.

重复应用吗啡可逐渐诱导离体豚鼠回肠出现挛缩。2. 诱导挛缩的最佳条件如下：吗啡的浓度、孵育时间和洗脱时间分别为1或10微摩尔、2分钟和3分钟。3. 用纳洛酮或河豚毒素预孵育可阻断这种吗啡诱导的挛缩。4. 在抑制抽搐的药物中，只有可乐定可诱导出与吗啡诱导的挛缩相似的挛缩，而河豚毒素（TTX）和腺苷则不会。5. 在纵行肌-肌间神经丛标本中也观察到了挛缩。6. 这些发现表明，吗啡对豚鼠回肠具有双重抑制和兴奋作用，且重复应用吗啡会优先减弱其抑制作用。

Kusama T, Murakoshi Y, Murakami H

Department of Physiology and Anatomy, Nihon University College of Pharmacy, Chiba, Japan.

Gen Pharmacol. 1992 May;23(3):391-6. doi: 10.1016/0306-3623(92)90100-x.

The repetitive application of morphine gradually induced a contracture in the isolated guinea pig ileum. 2. The optimum conditions for induction of the contracture were as follows: the concentration, incubation time and washout time of morphine were 1 or 10 microM, 2 and 3 min, respectively. 3. Preincubation with naloxone or TTX blocked this morphine-induced contracture. 4. Among twitch-inhibiting drugs, only clonidine induced a contracture similar to that induced by morphine, while tetrodotoxin (TTX) and adenosine did not. 5. The contracture was also observed in the longitudinal muscle-myenteric plexus preparations. 6. These findings indicate that morphine has a dual inhibitory and excitatory action on the guinea pig ileum and that its repetitive application preferentially diminish the inhibitory one.

重复应用吗啡可逐渐诱导离体豚鼠回肠出现挛缩。2. 诱导挛缩的最佳条件如下：吗啡的浓度、孵育时间和洗脱时间分别为1或10微摩尔、2分钟和3分钟。3. 用纳洛酮或河豚毒素预孵育可阻断这种吗啡诱导的挛缩。4. 在抑制抽搐的药物中，只有可乐定可诱导出与吗啡诱导的挛缩相似的挛缩，而河豚毒素（TTX）和腺苷则不会。5. 在纵行肌-肌间神经丛标本中也观察到了挛缩。6. 这些发现表明，吗啡对豚鼠回肠具有双重抑制和兴奋作用，且重复应用吗啡会优先减弱其抑制作用。