Garcia-Munoz M, Young S J, Groves P M
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla 92093-0603.
Neuroreport. 1992 Apr;3(4):357-60. doi: 10.1097/00001756-199204000-00017.
We employed measurements of striatal terminal excitability to monitor the presynaptic effects of tetanic stimulation of corticostriatal fibers. Cortical tetanic stimulation (CTS) initiated a long-lasting decrease in terminal excitability. With higher current CTS, a transient increase in excitability preceded the decrease. However, a long-term increase was induced (1) by a second tetanus applied during the brief elevation in excitability initiated by a previous CTS or (2) when dopamine and GABA transmission were disrupted. A long-term increase also occurred following tetanic stimulation of the striatal terminal field (STS). The direction of the long-lasting change in excitability may depend on the level of polarization of the membrane. These presynaptic mechanisms could be important for the long-term selective modification of striatal synaptic transmission.
我们采用纹状体终末兴奋性测量方法来监测皮质纹状体纤维强直刺激的突触前效应。皮质强直刺激（CTS）引发终末兴奋性的持久降低。在较高电流的CTS作用下，兴奋性在降低之前会有短暂升高。然而，（1）在先前CTS引发的兴奋性短暂升高期间施加第二次强直刺激，或（2）当多巴胺和GABA传递被破坏时，会诱导长期升高。纹状体终末场（STS）的强直刺激后也会出现长期升高。兴奋性持久变化的方向可能取决于膜的极化水平。这些突触前机制对于纹状体突触传递的长期选择性修饰可能很重要。
