膳食蛋白质对正常血压和自发性高血压大鼠肾小球血管紧张素II受体结合的影响。

Influence of dietary protein on glomerular angiotensin II-receptor binding in normotensive and spontaneously hypertensive rats.

Vaughan D L, Russell G I

Renal Research Laboratory, School of Postgraduate Medicine and Biological Sciences, University of Keele, Staffordshire, U.K.

Clin Sci (Lond). 1992 Jul;83(1):23-8. doi: 10.1042/cs0830023.

Abstract

The binding of angiotensin II to glomerular receptors was studied in spontaneously hypertensive and normotensive Wistar-Kyoto rats in response to 7, 16 and 32% isocaloric, isonatraemic protein diets. 2. Increased dietary protein elevated the systemic angiotensin II levels of both spontaneously hypertensive and Wistar-Kyoto rats [F0.05(2,26) = 4.758, P less than 0.05; n = 36], and this was not associated with changes in either systemic blood pressure or cortical renin activity. 3. Furthermore, no significant changes in the affinity or density of angiotensin II receptors were associated with changes of dietary protein intake in either strain. 4. These results indicate a dissociation between the system renin-angiotensin system and the tissue renin-angiotensin system in response to protein intake.

摘要

在自发性高血压和血压正常的Wistar-Kyoto大鼠中，研究了血管紧张素II与肾小球受体的结合情况，这些大鼠分别摄入7%、16%和32%的等热量、等钠蛋白质饮食。2. 增加饮食中的蛋白质含量会提高自发性高血压大鼠和Wistar-Kyoto大鼠的全身血管紧张素II水平[F0.05(2,26) = 4.758，P < 0.05；n = 36]，且这与全身血压或皮质肾素活性的变化无关。3. 此外，两种品系大鼠的血管紧张素II受体亲和力或密度均未随饮食蛋白质摄入量的变化而发生显著改变。4. 这些结果表明，肾素-血管紧张素系统对蛋白质摄入的反应中，全身肾素-血管紧张素系统与组织肾素-血管紧张素系统之间存在分离现象。