Chan T M, Pun K K, Cheng I K
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Nephrol Dial Transplant. 1992;7(8):835-9.
Total and regional bone mineral densities (BMD) of ten male haemodialysis (HD) patients and ten male patients on continuous ambulatory peritoneal dialysis (CAPD) were measured using dual-energy X-ray absorptiometry (DEXA), and compared with that of age- and sex-matched controls. Our data showed that patients with renal failure on dialysis had reduced bone densities as manifested by a reduction in total body BMD, femoral neck BMD, and Ward's triangle BMD. In addition, head BMD and femoral trochanter BMD were also reduced in HD patients. Among HD patients, the length of the period of dialysis correlated with serum level of parathyroid hormone and the reductions in total body BMD and head BMD. Furthermore, there was a strong negative correlation between bone density of the skull and serum parathyroid hormone. Our results demonstrated regional variations in the reduction of bone density in patients with asymptomatic renal bone disease. DEXA bone scan is a useful adjunct in the early assessment of renal osteodystrophy and bone density of the skull can be used as a monitor in hyperparathyroid bone disease.
使用双能X线吸收法（DEXA）测量了10名男性血液透析（HD）患者和10名男性持续性非卧床腹膜透析（CAPD）患者的全身和局部骨矿物质密度（BMD），并与年龄和性别匹配的对照组进行比较。我们的数据显示，透析的肾衰竭患者骨密度降低，表现为全身BMD、股骨颈BMD和沃德三角区BMD降低。此外，HD患者的头部BMD和股骨粗隆BMD也降低。在HD患者中，透析时间与甲状旁腺激素血清水平以及全身BMD和头部BMD的降低相关。此外，颅骨骨密度与血清甲状旁腺激素之间存在强烈的负相关。我们的结果表明，无症状肾性骨病患者骨密度降低存在区域差异。DEXA骨扫描是早期评估肾性骨营养不良的有用辅助手段，颅骨骨密度可作为甲状旁腺功能亢进性骨病的监测指标。
