Albert E D
MMW Munch Med Wochenschr. 1976 May 7;118(19):619-24.
The HL-A system is part of the main histocompatibility complex of man which is located on chromosome A6. The clinical importance of this antigen system lies in its application in the immunological choice of donor for transplantations, it being clear that still other important transplantation systems must be located on chromosome 6. The fact that in many diseases certain HL-A antigens occur more frequently has acquired a certain diagnostic significance in ankylosing spondylitis, iritis and juvenile rheumatoid arthritis. The associations with HL-A observed can best be explained by the assumption HL-A-coupled defective immunoresponse genes which are partly responsible for sensitivity to disease.
HL - A系统是人类主要组织相容性复合体的一部分，位于第6号染色体上。该抗原系统的临床重要性在于其在移植供体免疫选择中的应用，显然其他重要的移植系统也必定位于第6号染色体上。在许多疾病中某些HL - A抗原出现频率更高这一事实，在强直性脊柱炎、虹膜炎和青少年类风湿性关节炎中已具有一定的诊断意义。观察到的与HL - A的关联，最好用HL - A相关的缺陷免疫反应基因的假设来解释，这些基因部分地导致了对疾病的易感性。
