Norman M, Ekman G
Department of Obstetrics and Gynecology, Karolinska Institutet, Danderyd Hospital, Sweden.
Acta Obstet Gynecol Scand. 1992 Jul;71(5):351-5. doi: 10.3109/00016349209021072.
Thirty term pregnant women with one previous cesarean section and with unripe cervices were given 0.5 mg prostaglandin E2 in gel strictly intracervically for cervical ripening and labor induction. Fifteen out of these 30 women (50%) were vaginally delivered within 24 hours. The cervical ripening/labor induction was considered a failure in two women. In one woman, an episode of hypercontractility was registered. After tocolytic therapy the uterine activity was normalised and the woman had a normal vaginal delivery. The frequency of cesarean sections was 8/30 (27%). At the operations no insufficiencies in the uterine scars were noted. Conclusively, strict intracervical application of 0.5 mg prostaglandin E2 in gel can be used for cervical ripening and labor induction also in women with one previous cesarean section.
30名既往有一次剖宫产史且宫颈未成熟的足月孕妇，严格经宫颈给予0.5mg前列腺素E2凝胶用于促宫颈成熟和引产。这30名妇女中有15名（50%）在24小时内经阴道分娩。2名妇女的促宫颈成熟/引产被认为失败。1名妇女出现了宫缩过强的情况。经宫缩抑制剂治疗后，子宫活动恢复正常，该妇女经阴道正常分娩。剖宫产率为8/30（27%）。手术中未发现子宫瘢痕有缺陷。总之，严格经宫颈应用0.5mg前列腺素E2凝胶也可用于既往有一次剖宫产史妇女的促宫颈成熟和引产。
