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甲状腺功能减退大鼠骨骼肌纤维的细胞内钠和钾活性

Intracellular sodium and potassium activities of skeletal muscle fibres of hypothyroid rats.

作者信息

MacDermott M

机构信息

Department of Physiology, Royal College of Surgeons, Dublin, Ireland.

出版信息

Exp Physiol. 1992 Jul;77(4):649-52. doi: 10.1113/expphysiol.1992.sp003629.

DOI:10.1113/expphysiol.1992.sp003629
PMID:1326291
Abstract

In soleus muscle fibres of hypothyroid rats, the membrane potential (Vm) and the intracellular K+ activity (aKi) were significantly lower than in control muscles. These results are consistent with the well-documented decrease in the number of Na(+)-K+ pumps which occurs in hypothyroid muscles. aNai was unchanged in the hypothyroid muscles but this may reflect a change in passive Na+ fluxes which has been reported to occur in association with changes in the number of pump units.

摘要

在甲状腺功能减退大鼠的比目鱼肌纤维中,膜电位(Vm)和细胞内钾离子活性(aKi)显著低于对照肌肉。这些结果与甲状腺功能减退肌肉中钠钾泵数量减少这一有充分记录的现象一致。甲状腺功能减退肌肉中的细胞内钠离子(aNai)没有变化,但这可能反映了被动钠离子通量的变化,据报道这种变化与泵单位数量的变化有关。

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