Xu C T, Wang Y M
Department of Gastroenterology, Air Force Hospital, Lanzhou.
Zhonghua Yi Xue Za Zhi (Taipei). 1992 Jul;50(1):37-40.
To investigate the circadian change in the plasma atrial natriuretic peptide (ANP) concentrations and its relation to cyclic AMP (cAMP), cyclic GMP (cGMP) and serum sodium. This investigation was conducted on 22 normal subjects consisting of 16 men and 6 women with a mean age of 21.5 years. Blood samples, systolic blood pressure (SBP), and heart rate (HR), were collected and recorded every 8 hours during a 24 hour period. SBP and HR were highest at 1600 h (p less than 0.05). Plasma ANP concentrations at 0800 h (196.3 +/- 140.6 ng/L, p less than 0.01) and 1600 h (203.4 +/- 127.5 ng/L, p less than 0.01) were higher than at 2400 h (64.4 +/- 46.0 ng/L). Serum sodium, plasma cAMP, and cGMP were at the highest level at 1600 h (p less than 0.05). Plasma ANP correlated with plasma cAMP, cGMP, serum sodium, SBP, and HR (r = 0.378 - 0.419, p less than 0.05). This data supports the assumption that atrial wall distension seems to be a stimulus for ANP release.
为研究血浆心钠素（ANP）浓度的昼夜变化及其与环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）和血清钠的关系。本研究对22名正常受试者进行，其中包括16名男性和6名女性，平均年龄21.5岁。在24小时内每8小时采集并记录血样、收缩压（SBP）和心率（HR）。SBP和HR在16:00时最高（p<0.05）。08:00时（196.3±140.6 ng/L，p<0.01）和16:00时（203.4±127.5 ng/L，p<0.01）的血浆ANP浓度高于24:00时（64.4±46.0 ng/L）。血清钠、血浆cAMP和cGMP在16:00时处于最高水平（p<0.05）。血浆ANP与血浆cAMP、cGMP、血清钠、SBP和HR相关（r=0.378 - 0.419，p<0.05）。该数据支持心房壁扩张似乎是ANP释放刺激因素的假设。
