劳氏肉瘤病毒感染的鸡神经视网膜细胞衰老后转化表型的丧失。

Seigel G M, Notter M F

Department of Neurobiology and Anatomy, University of Rochester Medical Center, New York 14642.

J Virol. 1992 Oct;66(10):6242-7. doi: 10.1128/JVI.66.10.6242-6247.1992.

Success in obtaining permanent Rous sarcoma virus-infected chicken cell lines has been limited because of a senescence phenomenon. We show that a diminished, transformed phenotype, followed by dramatic morphological changes, precedes senescence. These changes are associated with continued expression of pp60v-src, as well as specific alterations in expression of two possible phosphorylated substrates of pp60v-src.

由于衰老现象，成功获得永久性劳斯肉瘤病毒感染的鸡细胞系受到限制。我们发现，在衰老之前，会出现一种减弱的转化表型，随后是显著的形态变化。这些变化与pp60v-src的持续表达以及pp60v-src两种可能的磷酸化底物表达的特定改变有关。