Moraru D
Clinica I Pediatrie, UMF Iaşi.
Pediatrie (Bucur). 1992 Jul-Sep;41(3):46-59.
The author discussed the principal pathological mechanisms of the essential hypertension, i.e the importance of sodium and natriuretic factor, the importance of the sympathetic nervous system in the adjustment of the blood pressure, the importance of the renin-angiotensin-aldosterone system, as well as the implication of the kidney by its pressor and depressor mechanisms. The authors emphasized the interrelation of the pressor mechanisms in the essential hypertension. He concluded that the essential hypertension is a "disease of a complex adjustment" with a clinical, biological, haemodynamic and therapeutic heterogeneity, that the genetic factor is well accepted, thus the identification of other genetic markers would have a great importance. There are also presented the principal groups of drugs used in the essential hypertension, in correlation with the pathological mechanisms.
作者讨论了原发性高血压的主要病理机制，即钠和利钠因子的重要性、交感神经系统在血压调节中的重要性、肾素 - 血管紧张素 - 醛固酮系统的重要性，以及肾脏通过其升压和降压机制所起的作用。作者强调了原发性高血压中升压机制的相互关系。他得出结论，原发性高血压是一种具有临床、生物学、血液动力学和治疗异质性的“复杂调节疾病”，遗传因素已被广泛接受，因此识别其他遗传标记具有重要意义。文中还介绍了与病理机制相关的用于原发性高血压的主要药物类别。
