Vogl T J, Jassoy A, Söllner O, Becker C, Hamburger C, Dadashi A, Sauter R, Lissner J
Radiologische Klinik Innenstadt, Universität München.
Rofo. 1992 Oct;157(4):371-7. doi: 10.1055/s-2008-1033025.
Twenty-two patients with intracranial tumours were examined by MR images and in vivo proton-MR-spectroscopy. The changes of relative concentrations of NAA, PCr/Cr, Cho, and Ins were measured spectroscopically and the amount of these metabolites were related to different tumour groups. Analysis of the results has shown that the spectra from all the tumours differed from normal spectra. All cerebral tumours showed marked reduction of the Pcr/Cho quotient and the NAA/Cho quotient was also reduced. The Ins/Cho quotient for meningiomas and metastases was also lower than in normals; in gliomas of low malignancy the quotient was slightly raised and in gliomas of greater malignancy it was significantly higher than normal. The spectra of cerebral metastases showed unusual high lipid signals of 0.9 ppm and 1.25 ppm. The only common feature for meningiomas was marked reduction of NAA concentration. In summary, localised in vivo proton-MR-spectroscopy can be used clinically to obtain valuable information for the differential diagnosis of gliomas and intracerebral metastases.
对22例颅内肿瘤患者进行了磁共振成像（MR）和活体质子磁共振波谱分析。通过波谱分析测量了NAA、PCr/Cr、Cho和Ins的相对浓度变化，并将这些代谢物的含量与不同肿瘤组相关联。结果分析表明，所有肿瘤的波谱均与正常波谱不同。所有脑肿瘤均显示Pcr/Cho商显著降低，NAA/Cho商也降低。脑膜瘤和转移瘤的Ins/Cho商也低于正常水平；低恶性胶质瘤的该商略有升高，高恶性胶质瘤的该商显著高于正常水平。脑转移瘤的波谱显示0.9 ppm和1.25 ppm处有异常高的脂质信号。脑膜瘤唯一的共同特征是NAA浓度显著降低。总之，局部活体质子磁共振波谱分析可在临床上用于获取有价值的信息，以鉴别诊断胶质瘤和脑内转移瘤。
