[高活性心房利钠肽（haANP）输注对妊娠高血压综合征患者的降压作用]

[Antihypertensive effects of highly active atrial natriuretic peptide (haANP) infusion in patients with pregnancy-induced hypertension].

作者信息

Zhang L

机构信息

2nd Hospital, Fourth Military Medical University, Xian.

出版信息

Zhonghua Yi Xue Za Zhi. 1992 Feb;72(2):68-70, 126.

PMID:1327434

Abstract

To study the antihypertensive effects of a new synthetic highly active atrial natriuretic peptide (haANP), the effects were observed in patients with moderate and severe pregnancy-induced hypertension (PIH). There were significant decreases in blood pressure (BP) for 10 min after haANP infusion (from 20.46 +/- 1.04/14.15 +/- 1.59 kPa to 18.17 +/- 0.60/11.08 +/- 1.36 kpa; P less than 0.05). 90 min after haANP infusion, BP decrease was the lowest (to 16.00 +/- 1.21/10.5 +/- 0.71 kPa; P less than 0.01), while plasma ANP levels increased 11 folds (from 47.5 +/- 5.5 ng/L to 525.4 +/- 15.6 ng/L). The effects continued for 300 minutes. Antihypertensive effects of magnesium sulphate were relatively relaxed (compared with those of haANP). The results showed strong and rapid antihypertensive effects of haANP. We found that mean RA and ALD levels were significantly decreased after haANP.

摘要

为研究一种新合成的高活性心房利钠肽（haANP）的降压作用，观察了其在中重度妊娠高血压综合征（PIH）患者中的效果。输注haANP后10分钟血压（BP）显著下降（从20.46±1.04/14.15±1.59千帕降至18.17±0.60/11.08±1.36千帕；P<0.05）。输注haANP后90分钟，血压下降幅度最低（降至16.00±1.21/10.5±0.71千帕；P<0.01），而血浆ANP水平升高了11倍（从47.5±5.5纳克/升升至525.4±15.6纳克/升）。这种作用持续300分钟。硫酸镁的降压作用相对较弱（与haANP相比）。结果显示haANP具有强大而快速的降压作用。我们发现输注haANP后平均肾素（RA）和醛固酮（ALD）水平显著降低。