Absher M P, Hemenway D R, Leslie K O, Trombley L, Vacek P
Department of Medicine, University of Vermont, Burlington 05405.
Exp Lung Res. 1992 Sep-Oct;18(5):743-57. doi: 10.3109/01902149209031705.
Short-term exposure of rats to aerosols of the silicon dioxide, cristobalite, leads to pulmonary inflammation persisting several months. Clearance of particles occurs during the first two weeks after cessation of exposure, after which there is little additional clearance in the whole lung. In the present studies, quantitation of silica in lung compartments at selected times following exposure indicated movement of particles between the alveolar space and the lung tissue per se, with increased alveolar silica content associated with decreased silica content in the tissue compartment. Further, changes in the silica content in the alveolar compartment were generally associated with fluctuations in the alveolar macrophage population. Silica accumulated linearly in the mediastinal lymph nodes and thymus for several months after cessation of exposure, while negligible amounts were found in kidney, spleen, liver, and blood. A compartmental model was used to describe the distribution and translocation kinetics of the inhaled silica in the lung and extrapulmonary tissues.
大鼠短期暴露于方石英二氧化硅气溶胶会导致持续数月的肺部炎症。在接触停止后的头两周内会发生颗粒清除，在此之后，整个肺部几乎没有额外的清除。在本研究中，在接触后选定时间对肺区室中的二氧化硅进行定量分析表明，颗粒在肺泡腔和肺组织本身之间移动，肺泡二氧化硅含量增加与组织区室中二氧化硅含量降低相关。此外，肺泡区室中二氧化硅含量的变化通常与肺泡巨噬细胞数量的波动有关。接触停止后数月，二氧化硅在纵隔淋巴结和胸腺中呈线性积累，而在肾脏、脾脏、肝脏和血液中发现的量可忽略不计。采用了一个区室模型来描述吸入的二氧化硅在肺和肺外组织中的分布及转运动力学。
