卵巢性索间质肿瘤和小细胞癌的凝集素组织化学

Lectin histochemistry of sex cord-stromal tumors and small cell carcinoma of the ovaries.

作者信息

Bychkov V, Deligdisch L, Talerman A, Reddy V B

机构信息

Department of Pathology, Mount Sinai School of Medicine, New York City, N.Y.

出版信息

Gynecol Obstet Invest. 1992;34(2):115-8. doi: 10.1159/000292739.

DOI:10.1159/000292739

PMID:1327998

Abstract

Binding sites of peanut agglutinin (PNA), Ulex europaeus (UEA-1), concanavalin A (Con A), and wheat germ agglutinin (WGA) were localized in 10 granulosa cell tumors, 10 Sertoli-Leydig cell tumors, 4 theca cell tumors, and 5 small cell carcinomas. Con A and WGA reacted positively with the majority of the studied neoplasms. PNA and UEA-1 were persistently negative in the sex cord-stromal tumors (SCST) but showed focal positivity in small cell carcinomas. Negative reactions of SCST with PNA and UEA-1 may serve for differentiation between them and common epithelial tumors that are usually PNA and UEA-1 positive.

摘要

花生凝集素（PNA）、荆豆凝集素（UEA-1）、刀豆球蛋白A（Con A）和麦胚凝集素（WGA）的结合位点在10例颗粒细胞瘤、10例支持-间质细胞瘤、4例卵泡膜细胞瘤和5例小细胞癌中进行了定位。Con A和WGA在大多数研究的肿瘤中呈阳性反应。PNA和UEA-1在性索间质肿瘤（SCST）中持续呈阴性，但在小细胞癌中显示局灶性阳性。SCST对PNA和UEA-1的阴性反应可用于它们与通常PNA和UEA-1阳性的常见上皮性肿瘤之间的鉴别。