Jaksic T, Yaman M, Thorner P, Wesson D K, Filler R M, Shandling B
Department of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
J Pediatr Surg. 1992 Oct;27(10):1315-7. doi: 10.1016/0022-3468(92)90284-e.
Pancreatic tumors are rare surgical problems in infants and children. A 20-year audit (1971 to 1991) of this institution showed six patients ranging in age from 3 weeks to 16 years who were operated on for pancreatic neoplasms. Five of these tumors were malignant, bringing the reported experience to 71 cases. This series of malignancies included three solid cystic tumors, one insulin-secreting tumor, and one pancreatoblastoma. The clinical presentations varied: three had abdominal pain, one developed hypoglycemia, and one had an abdominal mass with jaundice. In five of the six patients pancreatic pathology was suspected preoperatively. All were treated primarily with pancreatic resection including one pancreatoduodenectomy. No radiotherapy or chemotherapy was used. The perioperative mortality was 0% with a morbidity of 50%. The long-term results are encouraging, with all patients alive after a mean follow-up of 7.8 years. These data suggest that aggressive surgical therapy is warranted in the management of pediatric pancreatic tumors.
胰腺肿瘤在婴幼儿和儿童中是罕见的外科问题。该机构一项为期20年（1971年至1991年）的审计显示，有6例年龄从3周大到16岁的患者因胰腺肿瘤接受了手术。其中5例肿瘤为恶性，使报告的病例数达到71例。这一系列恶性肿瘤包括3例实性囊性肿瘤、1例胰岛素分泌肿瘤和1例胰腺母细胞瘤。临床表现各不相同：3例有腹痛，1例出现低血糖，1例有腹部肿块伴黄疸。6例患者中有5例术前怀疑胰腺病变。所有患者均首先接受了胰腺切除术，其中包括1例胰十二指肠切除术。未使用放疗或化疗。围手术期死亡率为0%，发病率为50%。长期结果令人鼓舞，所有患者在平均随访7.8年后均存活。这些数据表明，积极的手术治疗对于小儿胰腺肿瘤的管理是必要的。
