Suzuki T, Shiozaki Y, Masukawa Y, Misawa M, Nagase H
Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Jpn J Pharmacol. 1992 Apr;58(4):435-42. doi: 10.1254/jjp.58.435.
Effects of buprenorphine, U-50,488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the cocaine-induced place preference. Furthermore, the kappa-receptor agonist U-50,488H and the mu-receptor antagonist naltrexone both antagonized the cocaine preference. U-50,488H or naltrexone alone induced a place aversion in a dose-dependent manner. However, the cocaine-induced conditioned place preference was not blocked by lithium chloride, although the latter induced a conditioned place aversion, indicating that the antagonism of cocaine-induced place preference by U-50,488H or naltrexone does not result from a functional antagonism. These results suggest that mu- and kappa-opioid receptors may be involved in cocaine-induced conditioned place preference.
研究了丁丙诺啡、U-50,488H、纳曲酮和氯化锂对可卡因条件性位置偏爱效应的影响。丁丙诺啡，一种混合性阿片类激动剂-拮抗剂，阻断了可卡因诱导的位置偏爱。此外，κ-受体激动剂U-50,488H和μ-受体拮抗剂纳曲酮均拮抗可卡因偏爱。单独使用U-50,488H或纳曲酮以剂量依赖的方式诱导位置厌恶。然而，可卡因诱导的条件性位置偏爱未被氯化锂阻断，尽管后者诱导了条件性位置厌恶，这表明U-50,488H或纳曲酮对可卡因诱导的位置偏爱的拮抗作用并非源于功能性拮抗。这些结果提示μ-和κ-阿片受体可能参与了可卡因诱导的条件性位置偏爱。
