Lai H, Carino M A
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195.
Pharmacol Biochem Behav. 1992 Jul;42(3):553-8. doi: 10.1016/0091-3057(92)90155-9.
Acute (20 min) exposure to 100-dB white noise elicits a naltrexone-sensitive decrease in sodium-dependent high-affinity choline uptake in the frontal cortex and hippocampus of the rat. In the present study, the subtypes of opioid receptors involved were investigated by pretreating rats with microinjection of specific opioid-receptor antagonists into the lateral cerebroventricle before noise exposure. We found that the noise-induced decrease in high-affinity choline uptake in the hippocampus was blocked by pretreatment with either mu-, delta-, or kappa-opioid-receptor antagonists, whereas the effect of noise on frontal cortical high-affinity choline uptake was blocked by a mu- and delta- but not by a kappa-antagonist. These data further confirm the role of endogenous opioids in mediating the effects of noise on central cholinergic activity and indicate that different neural mechanisms are involved in the effects of noise on the frontal cortical and hippocampal cholinergic systems.
急性（20分钟）暴露于100分贝的白噪声会使大鼠额叶皮质和海马中钠依赖性高亲和力胆碱摄取量出现纳洛酮敏感的下降。在本研究中，通过在噪声暴露前向大鼠侧脑室微量注射特定阿片受体拮抗剂进行预处理，来研究涉及的阿片受体亚型。我们发现，海马中噪声诱导的高亲和力胆碱摄取量下降可被μ、δ或κ阿片受体拮抗剂预处理所阻断，而噪声对额叶皮质高亲和力胆碱摄取的影响可被μ和δ拮抗剂阻断，但不能被κ拮抗剂阻断。这些数据进一步证实了内源性阿片类物质在介导噪声对中枢胆碱能活性影响中的作用，并表明噪声对额叶皮质和海马胆碱能系统的影响涉及不同的神经机制。
