Karaçorlu S, Peyman G A, Karaçorlu M, Dunlap W, Soike K F
Louisiana State University Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Retina. 1992;12(3):261-4.
The toxicity of a new antiviral agent, 6-methoxypurine arabinoside (ara-M), as a selective and potent inhibitor against varicella-zoster virus, was investigated after intravitreal injection in rabbit eyes. Intravitreal doses of ara-M ranging from 20 micrograms to 400 micrograms produced no retinal toxicity, as assessed by electroretinography and light and transmission electron microscopy. These data suggest a potential role for intravitreal ara-M in the antiviral treatment of varicella-zoster viral retinitis.
一种新型抗病毒药物6-甲氧基嘌呤阿拉伯糖苷（ara-M）作为针对水痘-带状疱疹病毒的选择性强效抑制剂，其毒性在兔眼玻璃体内注射后进行了研究。通过视网膜电图、光学和透射电子显微镜评估，玻璃体内注射20微克至400微克剂量的ara-M未产生视网膜毒性。这些数据表明玻璃体内注射ara-M在水痘-带状疱疹病毒性视网膜炎的抗病毒治疗中具有潜在作用。
