Nakanishi S
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
Science. 1992 Oct 23;258(5082):597-603. doi: 10.1126/science.1329206.
The glutamate receptors mediate excitatory neurotransmission in the brain and are important in memory acquisition, learning, and some neurodegenerative disorders. This receptor family is classified in three groups: the N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate, and metabotropic receptors. Recent molecular studies have shown that many receptor subtypes exist in all three groups of the receptors and exhibit heterogeneity in function and expression patterns. This article reviews the molecular and functional diversity of the glutamate receptors and discusses their implications for integrative brain function.
谷氨酸受体介导大脑中的兴奋性神经传递，在记忆获取、学习以及一些神经退行性疾病中发挥重要作用。该受体家族分为三组：N-甲基-D-天冬氨酸（NMDA）受体、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）-海人藻酸受体和代谢型受体。最近的分子研究表明，这三组受体中均存在许多受体亚型，并且在功能和表达模式上表现出异质性。本文综述了谷氨酸受体的分子和功能多样性，并讨论了它们对大脑整合功能的影响。
