Bonaventure N, Kim M S, Jardon B, Yücel H
Centre de Neurochimie du CNRS, LNBC, Strasbourg, France.
Vision Res. 1992 Apr;32(4):611-20. doi: 10.1016/0042-6989(92)90177-k.
When injected into the chicken open eye, the GABA-agonist THIP and the GABA-antagonists bicuculline and picrotoxin induced spontaneous eye movements in nasal-temporal (N-T) and in temporal-nasal (T-N) direction, respectively. These spontaneous movements were scarcely modulated by optokinetic stimulation, irrespective of the direction of stimulation. It is suggested that they are due to the suppression of directional selectivity of retinal ganglion cells. When injected into the closed eye, GABAergic drugs did not produce spontaneous nystagmus. THIP provoked a reduction of the N-T component, without modifying the T-N one, while GABA antagonists induced a significant increase in OKN performance, especially for the N-T direction of stimulation. In these conditions, picrotoxin also provoked an increase in the duration of both components of optokinetic after nystagmus, indicating a direct effect of the drug upon the velocity-storage system.
当将γ-氨基丁酸（GABA）激动剂蝇蕈醇（THIP）以及GABA拮抗剂荷包牡丹碱和印防己毒素注入鸡的睁开的眼睛时，它们分别诱发了鼻颞侧（N-T）和颞鼻侧（T-N）方向的自发眼球运动。无论刺激方向如何，这些自发运动几乎不受视动刺激的调节。这表明它们是由于视网膜神经节细胞方向选择性的抑制所致。当注入闭合的眼睛时，GABA能药物不会产生自发性眼球震颤。蝇蕈醇使N-T成分减少，而不改变T-N成分，而GABA拮抗剂则使视动性眼震（OKN）表现显著增加，尤其是在N-T刺激方向上。在这些情况下，印防己毒素还使视动性眼震后眼震的两个成分的持续时间增加，表明该药物对速度存储系统有直接作用。
