Tsibul'skiĭ V L, Belyĭ V P
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Mar-Apr;42(2):211-25.
At the beginning the term "tolerance" determinations, given in different source of literature, have been considered. Further, the history of conditioned of tolerance and abuse creation from psycho-active drugs have been discussed. The hart of the article contains the critical points of the current representation of neurophysiological theory in the field of behavior, interaction mechanisms between live systems and drugs. The point of view, dominating in pharmacology science that tolerance is the direct result of drug substances intervention into the organism, has been opposed. Separation of primary and secondary physiological effects of drugs, allowed to the authors to conclude that the dominant role belongs to the state living system and to the presence of necessities during the motivation creations for the second drug use and to the tolerance changing.
一开始，我们考量了不同文献来源中给出的“耐受性”测定术语。此外，还讨论了精神活性药物产生耐受性和成瘾的历史。文章的核心包含了行为领域当前神经生理理论表述的关键点、生命系统与药物之间的相互作用机制。药理学领域中占主导地位的观点认为耐受性是药物物质干预机体的直接结果，本文对此观点提出了反对。药物主要和次要生理效应的区分，使作者们得出结论，即主导作用在于生命系统的状态、第二次使用药物动机形成过程中的需求存在以及耐受性的变化。
