Malignant T gamma/delta lymphoproliferative disease with natural killer lytic activity. - Suppr | 超能文献

Malignant T gamma/delta lymphoproliferative disease with natural killer lytic activity.

作者信息

Falcão R P, Voltarelli J C, Simões B P, Pestana D N, Zago M A, Figueiredo M S

机构信息

Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil.

出版信息

Am J Hematol. 1992 Oct;41(2):128-31. doi: 10.1002/ajh.2830410211.

DOI:10.1002/ajh.2830410211

Abstract

A 17-year-old girl presented with a lymphoproliferative disease involving the bone marrow, peripheral blood, and liver associated with reactive hyperplasia of the spleen. Neoplastic cells were atypical medium-sized lymphoblasts with convoluted nuclei and nucleoli without features of large granular lymphocytes (LGL). The phenotype was CD3+ CD4- CD8-, TCR alpha/beta-, TCR gamma/delta+, delta TCS1-, and CD16+, and these cells exhibited spontaneous natural killer (NK) activity. DNA analysis showed rearrangement of the TCR gamma gene but not of TCR beta or of Ig mu genes. This unusual lymphoproliferative disease may represent the neoplastic expansion of a minor subset of normal T gamma/delta cells with NK activity.

摘要

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