苯巴比妥、桂利嗪和唑沙宗对用野百合碱处理的大鼠右心室肥厚和高血压性肺血管疾病发展的影响。
Effects of phenobarbitone, cinnarizine, and zoxazolamine on the development of right ventricular hypertrophy and hypertensive pulmonary vascular disease in rats treated with monocrotaline.
作者信息
Kay J M, Smith P, Heath D, Will J A
出版信息
Cardiovasc Res. 1976 Mar;10(2):200-5. doi: 10.1093/cvr/10.2.200.
PMID:132989
Abstract
The results of this experiment suggest that the addition of zoxazolamine to the diet may prolong the survival and reduce the incidence of right ventricular hypertrophy and hypertensive pulmonary vascular disease in male rats given a single subcutaneous injection of monocrotaline. Phenobarbitone and cinnarizine were ineffective.
摘要
该实验结果表明，在单次皮下注射野百合碱的雄性大鼠饮食中添加唑沙宗，可能会延长其生存期，并降低右心室肥大和高血压性肺血管疾病的发生率。苯巴比妥和桂利嗪则无效。
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