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苯巴比妥、桂利嗪和唑沙宗对用野百合碱处理的大鼠右心室肥厚和高血压性肺血管疾病发展的影响。

Effects of phenobarbitone, cinnarizine, and zoxazolamine on the development of right ventricular hypertrophy and hypertensive pulmonary vascular disease in rats treated with monocrotaline.

作者信息

Kay J M, Smith P, Heath D, Will J A

出版信息

Cardiovasc Res. 1976 Mar;10(2):200-5. doi: 10.1093/cvr/10.2.200.

DOI:10.1093/cvr/10.2.200
PMID:132989
Abstract

The results of this experiment suggest that the addition of zoxazolamine to the diet may prolong the survival and reduce the incidence of right ventricular hypertrophy and hypertensive pulmonary vascular disease in male rats given a single subcutaneous injection of monocrotaline. Phenobarbitone and cinnarizine were ineffective.

摘要

该实验结果表明，在单次皮下注射野百合碱的雄性大鼠饮食中添加唑沙宗，可能会延长其生存期，并降低右心室肥大和高血压性肺血管疾病的发生率。苯巴比妥和桂利嗪则无效。

相似文献

1
Effects of phenobarbitone, cinnarizine, and zoxazolamine on the development of right ventricular hypertrophy and hypertensive pulmonary vascular disease in rats treated with monocrotaline.苯巴比妥、桂利嗪和唑沙宗对用野百合碱处理的大鼠右心室肥厚和高血压性肺血管疾病发展的影响。
Cardiovasc Res. 1976 Mar;10(2):200-5. doi: 10.1093/cvr/10.2.200.
2
Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.用野百合碱诱导肺动脉高压大鼠的血管紧张素转换酶活性与肺血管疾病的进展
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Magnesium aspartate hydrochloride attenuates monocrotaline-induced pulmonary artery hypertension in rats.盐酸门冬氨酸镁减轻大鼠野百合碱诱导的肺动脉高压。
Clin Sci (Lond). 1988 Dec;75(6):661-7. doi: 10.1042/cs0750661.
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Monocrotaline-induced cardiopulmonary injury in rats: modification by thiol and nonthiol ACE inhibitors.
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Chemical sympathectomy and serotonin inhibition reduce monocrotaline-induced right ventricular hypertrophy in rats.
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Supplemental oxygen reduces right ventricular hypertrophy in monocrotaline-injected rats.补充氧气可减轻注射了野百合碱的大鼠的右心室肥厚。
J Appl Physiol (1985). 1989 Apr;66(4):1642-8. doi: 10.1152/jappl.1989.66.4.1642.
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Pulmonary vasculature in monocrotaline-induced hypertensive rats on magnesium therapy.接受镁治疗的野百合碱诱导高血压大鼠的肺血管系统
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Changes in pulmonary structure and function induced by monocrotaline intoxication.
Am J Physiol. 1981 Feb;240(2):H149-55. doi: 10.1152/ajpheart.1981.240.2.H149.
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PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.血小板活化因子拮抗剂可抑制野百合碱诱导的肺损伤和肺动脉高压。
J Appl Physiol (1985). 1991 Dec;71(6):2483-92. doi: 10.1152/jappl.1991.71.6.2483.
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Protective effect of phenobarbitone against fulvine-induced hepatic damage and hypertensive pulmonary vascular disease in the rat.
Cardiovasc Res. 1973 Sep;7(5):655-63. doi: 10.1093/cvr/7.5.655.

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Lung angiotensin converting enzyme activity in rats with pulmonary hypertension.肺动脉高压大鼠的肺血管紧张素转换酶活性
Thorax. 1982 Mar;37(3):198-204. doi: 10.1136/thx.37.3.198.
6
Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.用野百合碱诱导肺动脉高压大鼠的血管紧张素转换酶活性与肺血管疾病的进展
Thorax. 1982 Feb;37(2):88-96. doi: 10.1136/thx.37.2.88.
7
Alteration of monocrotaline pyrrole-induced cardiopulmonary effects in rats by hydrallazine, dexamethasone or sulphinpyrazone.肼屈嗪、地塞米松或磺吡酮对大鼠中野百合碱吡咯诱导的心肺效应的影响。
Br J Pharmacol. 1984 Jun;82(2):375-80. doi: 10.1111/j.1476-5381.1984.tb10772.x.
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Effect of monocrotaline ingestion on the distribution of protein and angiotensin converting enzyme activity in the rat lung.野百合碱摄入对大鼠肺中蛋白质分布及血管紧张素转换酶活性的影响。
Thorax. 1986 Dec;41(12):914-8. doi: 10.1136/thx.41.12.914.