Swain C P, Tavill A S, Neale G
Gastroenterology. 1976 Sep;71(3):484-9.
Detailed studies of protein metabolism were undertaken in a patient with pellagra and hypoproteinemia associated with the carcinoid syndrome both before and after treatment. The synthesis of albumin improved from 82 mg per kg per day to 135 mg per kg per day with little change in the daily excretion of 5-hydroxyindole acetic acid. After treatment with nicotinamide the patient made good progress with a complete resolution of the signs of pellagra and protein malnutrition. These results support the hypothesis that a reduced availability of the essential amino acid L-tryptophan may limit the synthesis of albumin and nicotinic acid in patients with the carcinoid syndrome who become anoretic.
在一位患有糙皮病和与类癌综合征相关的低蛋白血症的患者治疗前后，对其蛋白质代谢进行了详细研究。白蛋白的合成从每天每千克82毫克提高到每天每千克135毫克，而5-羟吲哚乙酸的每日排泄量变化不大。用烟酰胺治疗后，患者病情好转，糙皮病和蛋白质营养不良的体征完全消失。这些结果支持了这样一种假说，即对于厌食的类癌综合征患者，必需氨基酸L-色氨酸的可用性降低可能会限制白蛋白和烟酸的合成。
