Barrett M S, Jones R N
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Eur J Clin Microbiol Infect Dis. 1992 May;11(5):462-5. doi: 10.1007/BF01961865.
Haemophilus influenzae strains with varied ampicillin resistance and beta-lactamase production patterns were tested against three investigational fluorinated quinolones (CI-960, fleroxacin, temafloxacin) using Haemophilus Test Medium (HTM) and National Committee for Clinical Laboratory Standards (NCCLS) methods. The disk diffusion zones and MICs were compared and regression statistics and scattergrams generated. The rank order of the agents according to activity against Haemophilus influenzae was CI-960 (MIC50 0.002 microgram/ml) greater than temafloxacin (MIC50 0.015 microgram/ml) greater than fleroxacin (MIC50 0.03 microgram/ml). The recommended susceptibility interpretive criteria for the 5-micrograms disks of each drug were: for CI-960 greater than or equal to 23 mm (MIC correlate less than or equal to 1 microgram/ml); for fleroxacin greater than or equal to 19 mm (MIC correlate less than or equal to 2 micrograms/ml); and for temafloxacin greater than or equal to 16 mm (MIC correlate less than or equal to 2 micrograms/ml). All recent Haemophilus influenzae isolates tested were susceptible to these potent fluoroquinolones and no interpretive errors were observed.
采用嗜血杆菌检测培养基（HTM）和美国国家临床实验室标准委员会（NCCLS）的方法，对具有不同氨苄西林耐药性和β-内酰胺酶产生模式的流感嗜血杆菌菌株进行了三种研究性氟化喹诺酮类药物（CI-960、氟罗沙星、替马沙星）的测试。比较了纸片扩散法抑菌圈直径和最低抑菌浓度（MIC），并生成了回归统计数据和散点图。根据对流感嗜血杆菌的活性，药物的排序为：CI-960（MIC50为0.002微克/毫升）＞替马沙星（MIC50为0.015微克/毫升）＞氟罗沙星（MIC50为0.03微克/毫升）。每种药物5微克纸片的推荐药敏解释标准为：CI-960≥23毫米（MIC对应值≤1微克/毫升）；氟罗沙星≥19毫米（MIC对应值≤2微克/毫升）；替马沙星≥16毫米（MIC对应值≤2微克/毫升）。所有测试的近期流感嗜血杆菌分离株对这些强效氟喹诺酮类药物均敏感，未观察到解释错误。
