Tabach R, De Moraes S
Department of Pharmacology, University of Sã Paulo, Brazil.
Eur J Pharmacol. 1992 Jun 17;216(3):449-51. doi: 10.1016/0014-2999(92)90445-a.
The effect of chronic ethanol pretreatment on the sensitivity of the transmurally stimulated mouse vas deferens to morphine was studied. Vasa deferentia isolated from ethanol-pretreated mice showed supersensitivity to the twitch inhibitory effect of morphine. The affinity of the vas deferens mu-opioid receptors for naloxone was increased. It is concluded that ethanol pretreatment induces mu-opioid receptor alterations which are, at least partially, responsible for the observed supersensitivity to morphine.
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