The development of acute tolerance to analgesia and the sensitivity changes in mouse vas deferens and ileum produced by morphine.
作者信息
Ramaswamy S, Pillai N P, Gopalakrishnan V, Ghosh M N
出版信息
Arch Int Pharmacodyn Ther. 1983 Feb;261(2):214-21.
PMID:6838282
Abstract
Repeated administration of morphine at 4 hr interval resulted in the development of tolerance to morphine-induced subsensitivity to acetylcholine in ileum and supersensitivity to norepinephrine in vas deferens of mouse. This was in parallel with analgesic tolerance to morphine. Pretreatment with naloxone antagonized the tolerance development to both morphine-induced analgesia and sensitivity changes, indicating a role for opiate receptors in this phenomenon.
摘要
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