Barbaccia M L, Roscetti G, Trabucchi M, Ambrosio C, Massotti M
Department of Experimental Medicine, University of Rome Tor Vergata, Italy.
Eur J Pharmacol. 1992 Sep 4;219(3):485-6. doi: 10.1016/0014-2999(92)90495-p.
Rat brain cortical minces were incubated with forskolin and dibutyryl-cyclic AMP for 60 and 30 min, respectively. The concentrations of pregnenolone, progesterone and desoxycorticosterone in this preparation were significantly increased by both substances. The results indicate that, in brain tissue, steroidogenesis appears to be regulated by receptor transduction mechanisms that operate through adenylate cyclase.
将大鼠脑皮质切碎物分别与福斯高林和二丁酰环磷腺苷温育60分钟和30分钟。这两种物质均使该制剂中孕烯醇酮、孕酮和脱氧皮质酮的浓度显著增加。结果表明，在脑组织中，类固醇生成似乎受通过腺苷酸环化酶起作用的受体转导机制调控。
