Sachinidis A, Weisser P, Ko Y, Schulte K, Meyer zu Brickwedde K, Neyses L, Vetter H
Medizinische Universitäts-Poliklinik, Bonn, Germany.
FEBS Lett. 1992 Nov 23;313(2):109-12. doi: 10.1016/0014-5793(92)81423-j.
The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.
