Sachsenheimer W, Piotrowski W, Bimmler T
Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Germany.
J Neurooncol. 1992 Jun;13(2):177-81. doi: 10.1007/BF00172768.
This prospective clinical trial (1983-1989) compares life-quality scores according to Karnofsky in patients with intra-cranial who had been operated upon. Karnofsky's performance status was evaluated during a follow-up period of 36 months. The patients were between 20 to 77 years of age; 132 patients had an astrocytoma grade III or IV; 42 patients with brain metastases were investigated; 72 had an astrocytoma grade I + II, and 144 had a meningioma. The median survival in patients with astrocytomas grade III or IV was 12 months; a short period with nearly normal activity (Karnofsky score 75) was followed by rapid deterioration. In patients with brain metastases, postoperatively the median functional ability reached its highest value three weeks after treatment and then decreased continuously (average score from 50-25). In patients with astrocytomas grade I and II, life-quality was reasonably good (mean score up to 75). The score was observed to increase slightly during the first year after treatment. A performance status improvement up to 80 could be obtained in patients with meningiomas; however, 35% were left unfit for work.
这项前瞻性临床试验（1983 - 1989年）比较了接受手术治疗的颅内疾病患者根据卡诺夫斯基评分得出的生活质量得分。在36个月的随访期内对卡诺夫斯基表现状态进行了评估。患者年龄在20至77岁之间；132例患者患有III级或IV级星形细胞瘤；对42例脑转移患者进行了研究；72例患有I + II级星形细胞瘤，144例患有脑膜瘤。III级或IV级星形细胞瘤患者的中位生存期为12个月；在一段活动接近正常的短暂时期（卡诺夫斯基评分75）之后，病情迅速恶化。脑转移患者术后中位功能能力在治疗后三周达到最高值，然后持续下降（平均评分从50降至25）。I级和II级星形细胞瘤患者的生活质量相当好（平均评分高达75）。观察到治疗后第一年评分略有增加。脑膜瘤患者的表现状态可改善至80，但35%的患者无法胜任工作。
