Ogihara M
Biochemical Pharmacology Group, Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Jpn J Pharmacol. 1992 Jul;59(3):413-6. doi: 10.1254/jjp.59.413.
The effects of nifedipine and nicardipine on glucagon-stimulated gluconeogenesis from lactate were examined in primary cultures of rat hepatocytes. Nifedipine and nicardipine (10(-7)-10(-5) M) significantly potentiated the glucagon-stimulated gluconeogenesis from lactate by increasing intracellular cAMP levels. In contrast, diltiazem and verapamil did not potentiate the glucagon-stimulated gluconeogenesis. 1-Methyl-3-isobutylxanthine and papaverine also potentiated the glucagon-stimulated gluconeogenesis from lactate. On the basis of these results, possible mechanisms by which nifedipine and nicardipine potentiate the glucagon-stimulated gluconeogenesis will be discussed.
在大鼠肝细胞原代培养物中研究了硝苯地平和尼卡地平对胰高血糖素刺激的乳酸糖异生的影响。硝苯地平和尼卡地平（10⁻⁷ - 10⁻⁵ M）通过增加细胞内cAMP水平，显著增强了胰高血糖素刺激的乳酸糖异生。相比之下，地尔硫卓和维拉帕米并未增强胰高血糖素刺激的乳酸糖异生。1-甲基-3-异丁基黄嘌呤和罂粟碱也增强了胰高血糖素刺激的乳酸糖异生。基于这些结果，将讨论硝苯地平和尼卡地平增强胰高血糖素刺激的乳酸糖异生的可能机制。
