异丙肾上腺素、4-甲基儿茶酚和血清对神经生长因子的诱导是通过三种不同机制实现的。
Induction of NGF by isoproterenol, 4-methylcatechol and serum occurs by three distinct mechanisms.
作者信息
Carswell S, Hoffman E K, Clopton-Hartpence K, Wilcox H M, Lewis M E
机构信息
Cephalon, Inc., West Chester, PA 19380.
出版信息
Brain Res Mol Brain Res. 1992 Sep;15(1-2):145-50. doi: 10.1016/0169-328x(92)90162-5.
Evidence is provided that isoproterenol, 4-methylcatechol and serum induce NGF by three separate mechanisms. Isoproterenol and 4-methylcatechol induced NGF and NGF mRNA in mouse fibroblast L929 cells in either the presence or absence of serum. Propranolol prevented NGF induction by isoproterenol, but not by 4-methylcatechol or serum. All possible combinations of these inducers resulted in additive increases in the levels of NGF and NGF mRNA.
有证据表明，异丙肾上腺素、4-甲基儿茶酚和血清通过三种不同机制诱导神经生长因子（NGF）。无论有无血清，异丙肾上腺素和4-甲基儿茶酚均可在小鼠成纤维细胞L929中诱导NGF和NGF mRNA。普萘洛尔可阻止异丙肾上腺素诱导NGF，但不能阻止4-甲基儿茶酚或血清诱导NGF。这些诱导剂的所有可能组合均导致NGF和NGF mRNA水平的累加增加。
Zotero 插件