环磷酸腺苷对氯离子向脉络丛 - 脑脊液系统转运的影响

Cyclic AMP alteration of chloride transport into the choroid plexus-cerebrospinal fluid system.

作者信息

Deng Q S, Johanson C E

机构信息

Department of Clinical Neurosciences, Brown University/Rhode Island Hospital, Providence 02903.

出版信息

Neurosci Lett. 1992 Aug 31;143(1-2):146-50. doi: 10.1016/0304-3940(92)90253-4.

DOI:10.1016/0304-3940(92)90253-4

PMID:1331900

Abstract

The permeation of 36Cl from blood into choroid plexus (CP) and cerebrospinal fluid (CSF) was studied in adult rats intraventricularly injected with either dibutyryl (db)-cAMP, theophylline with db-cAMP, or forskolin. All 3 treatments significantly enhanced the 15-min distribution (Vd) of 36Cl into CSF, by an average of 17-33%. In contrast, ouabain and acetazolamide (inhibitors of CSF production) reduced 36Cl uptake into CSF by 34% and 13%, respectively. A correlative analysis of the various treatments revealed that the volume of distribution of 36Cl in CSF varied inversely with that in the choroid plexus. This inverse relationship suggests drug effects on Cl movement across the apical (CSF-facing) membrane of CP.

摘要

在成年大鼠脑室内注射二丁酰（db）-环磷酸腺苷（cAMP）、茶碱与db-cAMP或福司可林后，研究了36Cl从血液进入脉络丛（CP）和脑脊液（CSF）的渗透情况。所有这三种处理均显著提高了36Cl在15分钟内进入脑脊液的分布容积（Vd），平均提高了17%-33%。相比之下，哇巴因和乙酰唑胺（脑脊液生成抑制剂）分别使36Cl进入脑脊液的摄取量降低了34%和13%。对各种处理的相关性分析表明，36Cl在脑脊液中的分布容积与在脉络丛中的分布容积呈反比。这种反比关系表明药物对氯离子跨脉络丛顶端（面向脑脊液）膜的移动有影响。