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使用葡萄糖水进行血液稀释的实验性体外循环中的脑脊液变化。

Cerebrospinal fluid changes in experimental cardiopulmonary bypass using hemodilution with glucose water.

作者信息

Ing T S, Wu C, Rosenberg J C, Ng P S, Su W, Bernard A A, Wilson R F

出版信息

Neurology. 1977 Jan;27(1):85-9. doi: 10.1212/wnl.27.1.85.

DOI:10.1212/wnl.27.1.85
PMID:13327
Abstract

Cardiopulmonary bypass using hemodilution with isotonic glucose water was performed on seven dogs. Intense systemic metabolic acidosis, hyponatremia, hypochloremia, and hyperglycemia were accompanied by only comparatively small changes in the corresponding cerebrospinal fluid values. The data suggested that in the present study, cardiopulmonary bypass was not associated with gross disruptions of the barriers for bicarbonate, sodium, chloride, and glucose between blood and cerebrospinal fluid.

摘要

对七只狗进行了使用等渗葡萄糖水进行血液稀释的体外循环。严重的全身性代谢性酸中毒、低钠血症、低氯血症和高血糖症仅伴随着相应脑脊液值相对较小的变化。数据表明,在本研究中,体外循环与血液和脑脊液之间的碳酸氢盐、钠、氯和葡萄糖屏障的严重破坏无关。

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Cerebrospinal fluid changes in experimental cardiopulmonary bypass using hemodilution with glucose water.使用葡萄糖水进行血液稀释的实验性体外循环中的脑脊液变化。
Neurology. 1977 Jan;27(1):85-9. doi: 10.1212/wnl.27.1.85.
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引用本文的文献

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Cardiopulmonary bypass increases permeability of the blood-cerebrospinal fluid barrier.体外循环会增加血脑屏障的通透性。
Ann Thorac Surg. 2010 Jan;89(1):187-94. doi: 10.1016/j.athoracsur.2009.09.030.
2
Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain.氨基酸(尤其是牛磺酸)、肌酸和电解质的适应性减少可预防慢性低钠血症小鼠的脑水肿:快速纠正(桥脑中央髓鞘溶解症的实验模型)会导致脑脱水和萎缩。
Metab Brain Dis. 1987 Dec;2(4):223-41. doi: 10.1007/BF00999694.