谷胱甘肽可抑制仙台病毒感染的培养细胞中病毒蛋白的复制和表达。
Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus.
作者信息
Garaci E, Palamara A T, Di Francesco P, Favalli C, Ciriolo M R, Rotilio G
机构信息
Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Italy.
出版信息
Biochem Biophys Res Commun. 1992 Nov 16;188(3):1090-6. doi: 10.1016/0006-291x(92)91343-o.
Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.
添加还原型谷胱甘肽可抑制仙台病毒在非洲绿猴肾（AGMK）细胞中的产生。这一结果可归因于谷胱甘肽对病毒复制的直接作用。这种抑制作用与细胞内谷胱甘肽水平的升高有关，而宿主细胞代谢未受影响。抗病毒作用与血凝素神经氨酸酶（HN）病毒糖蛋白的减少和失活有关。
Zotero 插件