Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus.
作者信息
Garaci E, Palamara A T, Di Francesco P, Favalli C, Ciriolo M R, Rotilio G
机构信息
Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Italy.
出版信息
Biochem Biophys Res Commun. 1992 Nov 16;188(3):1090-6. doi: 10.1016/0006-291x(92)91343-o.
PMID:1332709
Abstract
Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.
摘要
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