用电镀电鳐钠通道的光亲和标记法，采用携带放射性和发色重氮丙啶的光反应性μ-芋螺毒素。
Photoaffinity labeling of the electroplax sodium channel with a photoreactive mu-conotoxin carrying a radioactive and chromogenic diazirine.
作者信息
Hatanaka Y, Nakayama H, Kanaoka Y
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1992 Sep;40(9):2537-9. doi: 10.1248/cpb.40.2537.
PMID:1332832
Abstract
Photoreactive derivatives of mu-conotoxin GIIIA carrying a radioactive and chromogenic diazirine have been prepared as a photoaffinity labeling reagent for muscle-type sodium channels. When the reagent was photolyzed in the presence of the eel sodium channel, radioactivity was specifically incorporated into the channel protein.
摘要
携带放射性和显色重氮环丙烷的μ-芋螺毒素GIIIA的光反应性衍生物已被制备为用于肌肉型钠通道的光亲和标记试剂。当该试剂在鳗鱼钠通道存在下进行光解时，放射性会特异性地掺入通道蛋白中。
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