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Complementary use of counter-current chromatography and preparative reversed-phase high-performance liquid chromatography in the separation of a synthetic mixture of brominated tetrachlorofluoresceins.

作者信息

Weisz A, Scher A L, Andrzejewski D, Shibusawa Y, Ito Y

机构信息

Division of Colors and Cosmetics, US Food and Drug Administration, Washington, DC 20204.

出版信息

J Chromatogr. 1992 Aug 21;607(1):47-53. doi: 10.1016/0021-9673(92)87053-b.

DOI:10.1016/0021-9673(92)87053-b
PMID:1332984
Abstract

A synthetically prepared mixture of brominated 4,5,6,7-tetrachlorofloresceins was separated by a combination of preparative reversed-phase high-performance liquid chromatography and high-speed counter-current chromatography. Two new lower-brominated subsidiary colors of D&C Red Nos. 27 and 28 (phloxine B), 4',5'-dibromo-4, 5,6,7-tetrachlorofluorescein and 2',4',5'-tribromo-4,5,6, 7-tetrachlorofluorescein, were isolated and characterized by 1H NMR and chemical ionization mass spectrometry.

摘要

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