丙二醛分子与膜的相互作用。差示扫描量热法、¹H-、³¹P-NMR和ESR研究。
Interaction of the malonyldialdehyde molecule with membranes. A differential scanning calorimetry, 1H-, 31P-NMR and ESR study.
作者信息
Debouzy J C, Fauvelle F, Vezin H, Brasme B, Chancerelle Y
机构信息
CRSSA, unité de Biophysique, La Tronche, France.
出版信息
Biochem Pharmacol. 1992 Nov 3;44(9):1787-93. doi: 10.1016/0006-2952(92)90073-r.
The membrane interactions of malonyldialdehyde (MDA), natural product of polyunsaturated fatty acids peroxidation were investigated by differential scanning calorimetry, and ESR or NMR spectroscopy. This component is located in the superficial part of the bilayer, where it increases the local fluidity. High concentrations of MDA induce major membrane damage. Similar consequences of MDA-membrane interactions were observed on erythrocyte ghosts.
通过差示扫描量热法、电子自旋共振或核磁共振光谱研究了多不饱和脂肪酸过氧化的天然产物丙二醛（MDA）与膜的相互作用。该成分位于双层膜的表层，在那里它会增加局部流动性。高浓度的MDA会导致严重的膜损伤。在红细胞膜上也观察到了MDA与膜相互作用的类似结果。
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