肿瘤抑制基因。
Tumour suppressor genes.
作者信息
Cowell J K
机构信息
ICRF Oncology Group, Institute of Child Health, London, U.K.
出版信息
Ann Oncol. 1992 Nov;3(9):693-8. doi: 10.1093/oxfordjournals.annonc.a058319.
Abstract
Genes responsible for the hereditary predisposition to a variety of human cancers have now been isolated. Their function seems to be part of complex signalling pathways involved in the control of cellular differentiation and the cell cycle. The presence of a single copy of these genes appears to be sufficient to ensure normal development, i.e. prevents tumorigenesis, and has earned them the name--tumour suppressor genes.
摘要
现已分离出导致人类多种癌症遗传易感性的基因。它们的功能似乎是参与细胞分化和细胞周期控制的复杂信号通路的一部分。这些基因单拷贝的存在似乎足以确保正常发育，即预防肿瘤发生，这也为它们赢得了“肿瘤抑制基因”的名称。
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