从柔毛水杨梅中分离并鉴定一种抗病毒黄酮类化合物。

Isolation and characterization of an antiviral flavonoid from Waldsteinia fragarioides.

作者信息

Abou-Karam M, Shier W T

机构信息

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.

出版信息

J Nat Prod. 1992 Oct;55(10):1525-7. doi: 10.1021/np50088a022.

DOI:10.1021/np50088a022

PMID:1333516

Abstract

The antiviral agent in a fraction from Waldsteinia fragarioides (Rosaceae) was purified using bioassay-guided fractionation of activity against herpes simplex type 1 virus. Structural eluciation by instrumental methods identified the active component to be the known flavonoid glycoside, isoquercitrin (3,3',4',5,7-pentahydroxyflavone-3 beta-O-glucoside), which had not previously been shown to possess antiviral activity.

摘要

通过对委陵菜（蔷薇科）提取物中抗单纯疱疹病毒1型活性进行生物活性导向分级分离，纯化得到了抗病毒剂。通过仪器分析方法确定了活性成分是已知的黄酮苷异槲皮苷（3,3',4',5,7-五羟基黄酮-3β-O-葡萄糖苷），此前尚未发现其具有抗病毒活性。