Deugnier Y, Guyader D, Brissot P
Clinique des maladies du foie, hôpital Pontchaillou, Rennes.
Rev Prat. 1992 Sep 1;42(13):1639-42.
During the last past years, the curative and preventive treatment of hepatocellular carcinoma (HCC) has improved. The regular follow-up of patients with chronic liver disease using ultrasound examination and serum alpha-fetoprotein determination, leads to diagnose hepatocellular carcinoma at an early stage, when curative treatment could be quite efficient. Besides surgery which has been the only hope of cure for a few patients, efficient medical procedures--ie chemoembolization, in situ radiotherapy and alcohol injection--are emerging. The place of these different therapeutic procedures is to be defined. In addition, the prevalence of hepatocellular carcinoma should decrease due to the improvement of preventive policy--ie vaccination against hepatitis B infection and familial screening for genetic hemochromatosis.
在过去几年中,肝细胞癌(HCC)的治疗和预防取得了进展。通过超声检查和血清甲胎蛋白测定对慢性肝病患者进行定期随访,有助于在可进行有效根治性治疗的早期阶段诊断出肝细胞癌。除了手术(这一直是少数患者唯一的治愈希望)外,有效的医学手段——即化疗栓塞、原位放疗和酒精注射——正在兴起。这些不同治疗手段的地位有待明确。此外,由于预防措施的改进——即乙肝感染疫苗接种和遗传性血色素沉着症的家族筛查,肝细胞癌的发病率应该会下降。