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[氟罗坦对缺氧时肝脏脂质及环磷酸腺苷含量的影响]

[The effect of ftorotan on the lipid and cAMP content of the liver in hypoxia].

作者信息

Abidova S S, Ovchinnikov I V, Zhukova L V

出版信息

Eksp Klin Farmakol. 1992 May-Jun;55(3):33-4.

PMID:1333863
Abstract

A study was made of the content of cAMP, triglycerides and nonesterified fatty acids in the liver of rats anesthesized with halothane under conditions of spontaneous respiration depending on the oxygen content in the inhalation mixture. As the content of oxygen in the inhalation mixture was reduced, the content of cAMP in the liver was decreased, the intensity of lipolysis was disturbed with subsequent derangement of fatty acids oxidation. The raising of the oxygen content in the inhalation mixture did not disturb the activity of the adenylate cyclase system or provoked deep lipolysis disorders in the liver.

摘要

研究了在自主呼吸条件下,取决于吸入混合气中氧气含量,用氟烷麻醉的大鼠肝脏中cAMP、甘油三酯和非酯化脂肪酸的含量。随着吸入混合气中氧气含量降低,肝脏中cAMP含量下降,脂肪分解强度受到干扰,随后脂肪酸氧化紊乱。提高吸入混合气中氧气含量并未干扰腺苷酸环化酶系统的活性,也未引发肝脏中严重的脂肪分解紊乱。

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