Nordström E G, Niemi L, Miettinen J
Department of Chemical Engineering, Abo Akademi, Turku, Finland.
Biomed Mater Eng. 1992 Fall;2(3):115-21.
Slip cast conical implants of HA, carbonate-HA, calcium orthophosphate/hydroxyapatite and hydroxyapatite/calcium pyrophosphate/calcium orthophosphate with weight ratios 75/25 and 50/30/20 were implanted in rabbit tibia. The bone-implant interfaces were evaluated histologically, by means of SEM/EDX analysis and by push-out test. Thirty-six implanted samples were investigated after 2, 8, and 24 weeks. The triphasic calcium phosphate showed a moderate disintegration. This material showed 2 weeks after implantation a bonding between new bone and implant could be seen in parts of the operation site by SEM. Eight weeks after implantation an intimate relationship between the bone tissue and all specimens of each material was found. After 24 weeks the Ca/P ratio in the bone had reached the Ca/P ratio of mature bone determined by SEM/EDX analysis.
将重量比为75/25和50/30/20的羟基磷灰石（HA）、碳酸化羟基磷灰石、磷酸钙/羟基磷灰石以及羟基磷灰石/焦磷酸钙/磷酸钙的注浆成型锥形植入物植入兔胫骨。通过组织学、扫描电子显微镜/能谱分析（SEM/EDX）以及推出试验对骨-植入物界面进行评估。在2周、8周和24周后对36个植入样本进行研究。三相磷酸钙显示出中度分解。该材料在植入2周后通过SEM观察到，在手术部位的部分区域可见新骨与植入物之间存在结合。植入8周后，发现骨组织与每种材料的所有样本之间存在紧密关系。24周后，通过SEM/EDX分析确定骨中的钙磷比已达到成熟骨的钙磷比。
