大鼠胃底中β肾上腺素能受体占优势。
Preponderance of beta adrenergic receptors in the gastric fundus of the rat.
作者信息
Haque M A
出版信息
Pahlavi Med J. 1977 Jan;8(1):26-44.
There are two kinds of adrenergic receptors in rat fundus (stomach), the alpha receptors are stimulated with adrenaline and noradrenaline and can be blocked effectively with azapetine and the beta receptors are stimulated with isoprenaline and adrenaline and can be blocked effectively with propranolol. Adrenaline, noradrenaline and isoprenaline all produce inhibition of acetylcholine induced contractions in both untreated and reserpinized tissues that can be antagonized with azapetine and propranolol on its specific receptors but propranolol has a greater capacity to decrease the sensitivity of both untreated and reserpinized tissues to isoprenaline and adrenaline than azapetine can in case of noradrenaline and adrenaline.
大鼠胃底存在两种肾上腺素能受体，α受体可被肾上腺素和去甲肾上腺素激活，能被阿扎哌隆有效阻断；β受体可被异丙肾上腺素和肾上腺素激活，能被普萘洛尔有效阻断。肾上腺素、去甲肾上腺素和异丙肾上腺素均可抑制未处理及利血平化组织中乙酰胆碱诱导的收缩，这种抑制作用可被阿扎哌隆和普萘洛尔分别作用于其特异性受体所拮抗，但在降低未处理及利血平化组织对异丙肾上腺素和肾上腺素的敏感性方面，普萘洛尔的能力强于阿扎哌隆对去甲肾上腺素和肾上腺素的作用。
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