Fisher B M, Hepburn D A, Frier B M, Morton J J, Beastall G H, Gray C E, Buchanan K D
Department of Diabetes, Royal Infirmary, Glasgow, UK.
Eur J Clin Invest. 1992 Sep;22(9):614-8. doi: 10.1111/j.1365-2362.1992.tb01513.x.
To investigate the role of muscarinic cholinergic mechanisms in mediating the pancreatic and pituitary hormonal responses to hypoglycaemia, six normal subjects were studied during acute insulin-induced hypoglycaemia under control conditions, and during blockade with intravenous atropine. During atropine blockade the response of pancreatic polypeptide was suppressed while the maximum response of plasma glucagon was significantly higher. The increment in plasma vasopressin was also increased significantly during cholinergic blockade. During blockade with atropine the responses of plasma prolactin was reduced, with a slight but significant reduction in the growth hormone response, and although a similar maximum response of plasma ACTH was achieved, this rise was delayed. These results implicate involvement of a cholinergic muscarinic inhibitory and stimulatory mechanisms in regulating the responses of pancreatic and pituitary hormones to hypoglycaemia.
为研究毒蕈碱胆碱能机制在介导胰腺和垂体对低血糖的激素反应中的作用，对6名正常受试者在急性胰岛素诱导的低血糖状态下进行了对照研究，并在静脉注射阿托品阻断胆碱能机制期间进行了研究。在阿托品阻断期间，胰多肽的反应受到抑制，而血浆胰高血糖素的最大反应显著升高。在胆碱能阻断期间，血浆血管加压素的增量也显著增加。在阿托品阻断期间，血浆催乳素的反应降低，生长激素反应略有但显著降低，尽管血浆促肾上腺皮质激素达到了相似的最大反应，但这种升高延迟了。这些结果表明，胆碱能毒蕈碱抑制和刺激机制参与调节胰腺和垂体激素对低血糖的反应。
