Fisher B M, Thornton S, Hepburn D A, Morton J J, Baylis P H, Beastall G H, Gray C E, Frier B M
Diabetic Department, Royal Infirmary, Glasgow, UK.
Acta Endocrinol (Copenh). 1991 Oct;125(4):372-7. doi: 10.1530/acta.0.1250372.
Arginine vasopressin, oxytocin and ACTH are released from the pituitary gland in response to acute hypoglycemia. To investigate the role of alpha-adrenergic mechanisms in mediating this response, 6 non-diabetic subjects were studied during hypoglycemia induced by 0.15 IU/kg i.v. insulin under control conditions, and during non-selective alpha-adrenergic blockade with phentolamine. In the control study plasma arginine vasopressin rose from 1.6 +/- 0.8 pmol/l (mean +/- SEM) basally to a maximum of 2.5 +/- 0.8 pmol/l following hypoglycemia (p less than 0.05). An exaggerated response was found during phentolamine blockade, with a maximum plasma vasopressin of 11.5 +/- 0.4 pmol/l (by analysis of variance, p less than 0.05). The plasma oxytocin response to hypoglycemia was similarly increased during phentolamine compared to control. Plasma growth hormone rose to 94 +/- 19 mU/l, and during blockade with phentolamine the response was significantly reduced reaching a peak of 34 +/- 7 mU/l (by analysis of variance, p less than 0.05). ACTH and prolactin both increased in response to hypoglycemia, but the increases were not affected by phentolamine. An alpha-adrenergic mechanism appears to inhibit the release of arginine vasopressin and oxytocin in response to hypoglycemia, but does not appear to affect the secretion of ACTH.
精氨酸加压素、催产素和促肾上腺皮质激素在急性低血糖时从垂体释放。为了研究α-肾上腺素能机制在介导这一反应中的作用，对6名非糖尿病受试者在以下两种情况下进行了研究：一是在对照条件下静脉注射0.15 IU/kg胰岛素诱导低血糖期间，二是在使用酚妥拉明进行非选择性α-肾上腺素能阻滞期间。在对照研究中，血浆精氨酸加压素基础值为1.6±0.8 pmol/l（均值±标准误），低血糖后升至最高2.5±0.8 pmol/l（p<0.05）。在酚妥拉明阻滞期间发现反应过度，血浆加压素最高值为11.5±0.4 pmol/l（方差分析，p<0.05）。与对照相比，酚妥拉明期间血浆催产素对低血糖的反应同样增加。血浆生长激素升至94±19 mU/l，在酚妥拉明阻滞期间反应显著降低，峰值为34±7 mU/l（方差分析，p<0.05）。促肾上腺皮质激素和催乳素均对低血糖有反应性升高，但升高不受酚妥拉明影响。α-肾上腺素能机制似乎抑制精氨酸加压素和催产素对低血糖的释放，但似乎不影响促肾上腺皮质激素的分泌。
