Differing actions of beta-(2-thienyl)-gamma-aminobutyric acid in central and peripheral preparations.
作者信息
Ong J, Kerr D I, Berthelot P, Vaccher C, Flouquet N, Debaert M
机构信息
Department of Anaesthesia and Intensive Care, University of Adelaide, South Australia.
出版信息
Eur J Pharmacol. 1992 Oct 6;221(1):145-9. doi: 10.1016/0014-2999(92)90784-2.
In the guinea-pig isolated ileum, beta-(2-thienyl)-gamma-aminobutyric acid (BTG; 100-500 microM) reversibly and competitively (pA2 = 4.3 +/- 0.1) antagonised the baclofen-induced (5-100 microM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice preparations, BTG (100-500 microM) acted as an agonist, abolishing the frequency and amplitude of spontaneous discharges, sensitive to 2-hydroxysaclofen (100-500 microM). BTG exhibits differential actions at GABAB receptors in brain and periphery.
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